Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free (MALS verified) | IT6-M52W9-100ug

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SKU:
716-IT6-M52W9-100ug
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Size:
100 ug
€592.00
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Description

Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free (MALS verified) | IT6-M52W9-100ug| Gentaur Distribution US, UK & Europe

Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.

Source: Mouse ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free (IT6-M52W9) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 988 (ITGAV) & Gly 22 - Pro 708 (ITGB6) (Accession # P43406-1 (ITGAV) & Q9Z0T9-1 (ITGB6) ).

Format: Powder.

Tag: C-10×His | Native.

Expression System: HEK293.

Expression Region: Phe 31 - Val 988 (ITGAV) & Gly 22 - Pro 708 (ITGB6).

Conjugate: Unconjugated.

Molecular Weight: 112.5 kDa (ITGAV) & 80.2 kDa (ITGB6).

Characteristics: Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB6, has a calculated MW of 112.5 kDa (ITGAV) and 80.2 kDa (ITGB6). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB6 contains no tag but a basic tail at the C-terminus. The predicted N-terminus is Phe 31 (ITGAV) & Gly 22 (ITGB6). The non-reducing (NR) protein migrates as 135-145 kDa (ITGAV) & 80-90 kDa (ITGB6) respectively due to glycosylation.

Purity: 90%.

Buffer: 50 mM Tris, 150 mM NaCl, pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT

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