Mouse IL-23 R Protein, Fc Tag | ILR-M5251-100ug

Mouse IL-23 R Protein, Fc Tag | ILR-M5251-100ug| Gentaur Distribution US, UK & Europe

Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Source: Mouse IL-23R, Fc Tag (ILR-M5251) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Asp 372 (Accession # Q8K4B4-1).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Gly 24 - Asp 372.

Conjugate: Unconjugated.

Molecular Weight: 66.8 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 66.8 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT