Mouse GDNF / ATF Protein, His Tag (MALS verified) | GDF-M5245-20ug

Mouse GDNF / ATF Protein, His Tag (MALS verified) | GDF-M5245-20ug| Gentaur Distribution US, UK & Europe

GDNF promotes the survival and differentiation of neurons in culture, and is able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease. GDNF enhances survival and morphological differentiation of neurons and increases their high-affinity uptake.

Source: Mouse GDNF, His Tag (GDF-M5245) is expressed from human 293 cells (HEK293). It contains AA Ser 78 - Ile 211 (Accession # P48540).

Format: Powder.

Tag: N-10×His.

Expression System: HEK293.

Expression Region: Ser 78 - Ile 211.

Conjugate: Unconjugated.

Molecular Weight: 17.0 kDa.

Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 17.0 kDa. The protein migrates as 16 kDa, 18 kDa and 22-24 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT