Mouse FER, GST-tag | 40419

Mouse FER, GST-tag | 40419 | Gentaur US, UK & Europe Disrtribition

Category: Kinase/Cytoplasmic Tyrosine

Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

Background: FER is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. FER plays a role in regulating cytoskeletal rearrangements and inside out signalling that accompany receptor ligand, cell matrix and cell cell interactions (1). Genetic analysis using transgenic mouse models implicate FER in the regulation of inflammation and innate immunity. Fer-deficient mice displayed enhanced recruitment of leukocytes in response to local LPS challenge. FER is required for cell-cycle progression in malignant cells. Decreasing the level of FER using RNAi impeded the proliferation of prostate and breast carcinoma cells and led to their arrest at the G0/G1 phase (2).

Description: Recombinant mouse FER (a.a. 542-end), with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.

Product Type: Protein

Shippement Condition: -80°C