Mouse EPHB1, GST-tag | 40199

Mouse EPHB1, GST-tag | 40199 | Gentaur US, UK & Europe Disrtribition

Category: Kinase/Receptor Tyrosine

Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

Background: EPHB1 is a member of the Eph family of receptor tyrosine kinases. Ligand-activated EPHB1 forms a signaling complex with Nck, paxillin, and focal adhesion kinase and induces tyrosine phosphorylation of paxillin in a c-Src-dependent manner to promote cell migration (1). In addition, activated EPHB1 recruits the adaptor proteins Grb2 and p52Shc and promotes p52Shc and c-Src tyrosine phosphorylation as well as MAPK/extracellular signal-regulated kinase (ERK) activation. Expression of dominant-negative c-Src significantly reduced EPHB1-dependent ERK1/2 activation and chemotaxis (2).

Description: Recombinant mouse EPHB1 (a.a. 591-end), with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.

Product Type: Protein

Shippement Condition: -80°C