Mouse CD206 / MMR Protein, His Tag | CD6-M52H7-1mg

Mouse CD206 / MMR Protein, His Tag | CD6-M52H7-1mg| Gentaur Distribution US, UK & Europe

Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse.

Source: Mouse CD206 Protein, His Tag (CD6-M52H7) is expressed from human 293 cells (HEK293). It contains AA Leu 20 - Ala 1388 (Accession # Q61830).

Format: Powder.

Tag: C-10×His.

Expression System: HEK293.

Expression Region: Leu 20 - Ala 1388.

Conjugate: Unconjugated.

Molecular Weight: 157.3 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 157.3 kDa. The protein migrates as 150-180 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT