Description
Mouse B7-H3 / CD276 Protein, Fc Tag (MALS verified) | B73-M5255-1mg| Gentaur Distribution US, UK & Europe
B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.
Source: Mouse B7-H3, Fc Tag (B73-M5255) is expressed from human 293 cells (HEK293). It contains AA Val 29 - Phe 244 (Accession # NP_598744).
Format: Powder.
Tag: C-Fc.
Expression System: HEK293.
Expression Region: Val 29 - Phe 244.
Conjugate: Unconjugated.
Molecular Weight: 50.1 kDa.
Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.1 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: Tris with Glycine, Arginine and NaCl, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
