Mouse Alpha-Synuclein Protein, His Tag (MALS verified) | ALN-M52H6-1mg

Mouse Alpha-Synuclein Protein, His Tag (MALS verified) | ALN-M52H6-1mg| Gentaur Distribution US, UK & Europe

Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

Source: Mouse Alpha-Synuclein, His Tag (ALN-M52H6) is expressed from E.coli cells. It contains AA Met 1 - Ala 140 (Accession # O55042-1).

Format: Powder.

Tag: C-10×His.

Expression System: E. coli.

Expression Region: Met 1 - Ala 140.

Conjugate: Unconjugated.

Molecular Weight: 16.4 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.4 kDa. The protein migrates as 19-21 kDa under reducing (R) condition (SDS-PAGE).

Purity: 95%.

Buffer: 100 mM NaAC, pH7.0.

Storage Conditions: -20℃.

Shipping Conditions: RT