Monoclonal Anti-Human CD3 Antibody, Mouse IgG2a (Clone: OKT3), premium grade | CDE-M120a-500ug

Monoclonal Anti-Human CD3 Antibody, Mouse IgG2a (Clone: OKT3), premium grade | CDE-M120a-500ug| Gentaur Distribution US, UK & Europe

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

Source: Monoclonal AntiN/AHuman CD3 Antibody, Mouse IgG2a (Clone: OKT3), premium grade (CDEN/AM120a) is recombinantly produced from human 293 cells (HEK293) .

Molecule: CD3.

Species: Mouse.

Tag: Mouse IgG2a | Mouse kappa.

Conjugate: Unconjugated.

Purity: 95%.

Charactirization: PBS, pH7.4.

Storage Conditions: -70℃.

Shipping Conditions: Dry ice