Monoclonal Anti-G4S linker Antibody, Mouse IgG1 (163) (MALS verified) | G4S-M635-20ug

Monoclonal Anti-G4S linker Antibody, Mouse IgG1 (163) (MALS verified) | G4S-M635-20ug| Gentaur Distribution US, UK & Europe

The poly-Glycine-Serine (G4S) linker is a type of flexible, unstructured synthetic peptide linker sequence often leveraged to connect the variable heavy (VH) domain and variable light (VL) domain of single-chain variable fragments (scFvs) and chimeric antigen receptors (CARs) that utilize an extracellular domain scFv for target antigen recognition. The linker itself consists of a core pentapeptide sequence, Gly-Gly-Gly-Gly-Ser, that is repeated and commonly found as either a 15-mer (G4S) 3 or20-mer (G4S) 4 within scFv-based CARs and scFv fragments. The linker sequence length plays a role in controlling scFv stability and the noncovalent association between the VH and VL domains.

Source: The polyN/AGlycineN/ASerine (G4S) linker is a type of flexible, unstructured synthetic peptide linker sequence often leveraged to connect the variable heavy (VH) domain and variable light (VL) domain of singleN/Achain variable fragments (scFvs) and chimeric antigen receptors (CARs) that utilize an extracellular domain scFv for target antigen recognition. The linker itself consists of a core pentapeptide sequence, GlyN/AGlyN/AGlyN/AGlyN/ASer, that is repeated and commonly found as either a 15N/Amer (G4S) 3 or20N/Amer (G4S) 4 within scFvN/Abased CARs and scFv fragments. The linker sequence length plays a role in controlling scFv stability and the noncovalent association between the VH and VL domains.

Molecule: G4S linker.

Species: Mouse.

Tag: Mouse IgG1 | Mouse Kappa.

Conjugate: Unconjugated.

Purity: 90%.

Charactirization: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT