MMP3 Antibody / Matrix Metalloproteinase 3 | V7960-100UG

MMP3 Antibody / Matrix Metalloproteinase 3 | V7960-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: 1B4

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: ELISA

Buffer: N/A

Limitation: This Matrix Metalloproteinase 3 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.

Immunogen: Amino acids 317-327 from the human protein were used as the immunogen for this Matrix Metalloproteinase 3 antibody.

Storage: Store the Matrix Metalloproteinase 3 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).