Description
MMP2 Antibody | F53512-0.1ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In ascites with 0.09% sodium azide
Format: Ascites
Clone: 6E3F8
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: WB, IHC, ELISA
Buffer: N/A
Limitation: This MMP2 antibody is available for research use only.
Purity: Ascites
Description: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.
PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. [UniProt]
Immunogen: This MMP2 antibody was produced from mouse immunized with MMP2 recombinant protein.
Storage: Aliquot the MMP2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
