MLL1/WDR5/Ash2L/RbBP5 (MLL1/WAR Complex), His-tag | 51022

MLL1/WDR5/Ash2L/RbBP5 (MLL1/WAR Complex), His-tag | 51022 | Gentaur US, UK & Europe Disrtribition

Category: Methyltransferase/Enzymes

Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

Background: MLL is a histone methyltransferase that plays an essential role in early development and hematopoiesis. Part of a multiprotein complex that mediates both methylation of Lys4 of histone H3 (H3K4me) complex and acetylation of Lys16 of histone H4 (H4K16ac). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias.

Description: MLL1/WAR complex of human MLL1 (GenBank Accession No. NM_005933), a.a. 3745-end with N-terminal His-tag and MW= 27 kDa, human Ash2L (GenBank Accession No. NM_001105214), a.a. 2-end with N-terminal His-tag and MW= 61 kDa, and human RbBP5 (GenBank Accession No. NM_005057), a.a. 2-end with N-terminal His-tag and MW= 60 kDa, individually expressed in an E. coli expression system, and human WDR5 (GenBank Accession No. NM_017588), a.a. 2-end with N-terminal His-tag and MW= 37.4 kDa expressed in a baculovirus Sf9 expression system.

Product Type: Recombinant Protein Complex

Shippement Condition: -80°C