Description
MLF1 Antibody | F54428-0.4ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse
Application: IHC-P, FACS, WB
Buffer: N/A
Limitation: This MLF1 antibody is available for research use only.
Purity: Antigen affinity purified
Description: MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. The protein interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. It suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Immunogen: A portion of amino acids 215-244 from the human protein was used as the immunogen for the MLF1 antibody.
Storage: Aliquot the MLF1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
