Description
Mitofusin 2 Antibody / MFN2 | RQ4802 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: Antibody in PBS with 0.02% sodium azide and 50% glycerol
Format: Purified
Clone: AOCA-13
Host Animal: Rabbit
Clonality: Rabbit Monoclonal
Species Reactivity: Human, Mouse
Application: WB
Buffer: N/A
Limitation: This Mitofusin 2 antibody is available for research use only.
Purity: Affinity purified
Description: Mitofusin 2 is a mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria. [UniProt]
Immunogen: A synthetic peptide specific to human Mitofusin 2 / MFN2 was used as the immunogen for the Mitofusin 2 antibody.
Storage: Store the Mitofusin 2 antibody at -20 °C.
