Mitofusin 1 Antibody / MFN1 | RQ6027

Mitofusin 1 Antibody / MFN1 | RQ6027 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water

Format: Purified

Clone: 3H3

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: WB, IF

Buffer: Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide

Limitation: This Mitofusin 1 antibody is available for research use only.

Purity: Affinity purified

Description: Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene. It is an 80-90 kDa mitochondrial member of the dynamin family of molecules. It is ubiquitously expressed, and found in the outer mitochondrial membrane. The protein encoded by this gene is a mediator of mitochondrial fusion, and thereby contribute to the dynamic balance between fusion and fission that determines mitochondria morphology. MFN1 is known to form oligomers, either with itself or MFN�2, and to undergo ubiquitination by MARCH5. MFN�1 has two key domains. One is a coiled�coil region that mediates MFN�1: MFN�1/2 binding, and a second is a GTPase domain whose cleavage of GTP is necessary for membrane fusion. Overexpression of MFN1 caused perinuclear mitochondrial clustering.

Immunogen: Amino acids DQLLEFVTEGSHFVEATYKNPELDRIA from the human protein were used as the immunogen for the Mitofusin 1 antibody.

Storage: After reconstitution, the Mitofusin 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.