Mitochondrial Marker Antibody | V2352-100UG

Mitochondrial Marker Antibody | V2352-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Format: Purified

Clone: 113-1

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IF, WB, IHC-P

Buffer: N/A

Limitation: This Mitochondrial marker antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: Clone 113-1 antibody recognizes a 60kDa antigen that is a mitochondrial marker in human cells. Immunostaining produces a spaghetti-like pattern in normal and malignant cells. This mitochondrial marker antibody is an excellent marker for human cells in xenographic model research. Abundant granular eosinophilic cytoplasm is a common feature of renal oncocytoma, chromophobe renal cell carcinoma, eosinophilic variant of papillary renal cell carcinoma, and the granular variant of clear cell renal cell carcinoma (RCC). The chief reason for their distinction from one another is the difference in their biologic behavior. However, precise characterization may be difficult in some cases because of overlapping morphologic features. Immunostaining pattern with this mitochondrial marker antibody has been reported as a useful discriminatory adjunct in the complex differential diagnosis of granular renal cell tumors. Salivary gland tumors usually show great variability both in their morphopathology as well as their clinical behavior. One study highlights the usefulness of this mitochondrial marker antibody to facilitate the classification of salivary tumors, an aspect that may sometimes have not only diagnostic implications, but also prognostic.

Immunogen: A semi-purified mitochondrial preparation was used as the immunogen for this Mitochondrial marker antibody.

Storage: Store the Mitochondrial Marker antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).