Description
Mib1 Antibody (Mindbomb) | F47999-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: IF, IHC, WB, ELISA
Buffer: N/A
Limitation: This Mib1 antibody is available for research use only.
Purity: Purified
Description: MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
Immunogen: A portion of amino acids 13-42 from the human protein was used as the immunogen for this Mib1 antibody.
Storage: Aliquot the Mib1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
