Mib1 Antibody | F47999-0.4ML

Mib1 Antibody | F47999-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: IF, IHC, WB, ELISA

Buffer: N/A

Limitation: This Mib1 antibody is available for research use only.

Purity: Purified

Description: MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.

Immunogen: A portion of amino acids 13-42 from the human protein was used as the immunogen for this Mib1 antibody.

Storage: Aliquot the Mib1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.