MFN1 Antibody | R31677

MFN1 Antibody | R31677 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse, Rat

Application: WB

Buffer: N/A

Limitation: This MFN1 antibody is available for research use only.

Purity: Antigen affinity

Description: Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene. It is a mitochondrial member of the dynamin family of molecules. It is ubiquitously expressed, and found in the outer mitochondrial membrane. The protein encoded by this gene is a mediator of mitochondrial fusion, and thereby contribute to the dynamic balance between fusion and fission that determines mitochondria morphology. MFN1 is known to form oligomers, either with itself or MFN­2, and to undergo ubiquitination by MARCH5. It has two key domains; One is a coiled­coil region that mediates MFN­1/2 binding, and a second is a GTPase domain whose cleavage of GTP is necessary for membrane fusion. Overexpression causes perinuclear mitochondrial clustering.

Immunogen: An amino acid sequence from the N-terminal of human Mitofusin 1 (DQLLEFVTEGSHFVEATYKNPELDRIA) was used as the immunogen for this MFN1 antibody.

Storage: After reconstitution, the MFN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.