Description
METTL14 Antibody (N-Terminal Region) | F54217-0.2ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal
Species Reactivity: Human, Mouse
Application: WB
Buffer: N/A
Limitation: This METTL14 antibody is available for research use only.
Purity: Peptide affinity purified
Description: N6-adenosine-methyltransferase subunit METTL14 is an N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and self-renewal of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing and processing and mRNA stability. M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding developmental regulators, results in transcript destabilization, maintaining the groung state of ESCs, thereby promoting self-renewal of ESCs.
Immunogen: A portion of amino acids 2-36 from the N-terminal region of the human protein was used as the immunogen for the METTL14 antibody.
Storage: Aliquot the METTL14 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
