MERS Nucleocapsid protein, His Tag | NUN-M52H5-1mg

MERS Nucleocapsid protein, His Tag | NUN-M52H5-1mg| Gentaur Distribution US, UK & Europe

Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology; 517: 62-68). The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.

Source: MERS Nucleocapsid protein, His Tag (NUN-M52H5) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Asp 413 (Accession # K0BVN3-1).

Format: Powder.

Tag: C-6×His.

Expression System: HEK293.

Expression Region: Met 1 - Asp 413.

Conjugate: Unconjugated.

Molecular Weight: 46.7 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. This protein contains a furin cleavage site,  251-RHKR-254,  and is partially processed into N and C-terminal fragment with calculated MW of 17.1 kDa and 19.7 kDa respectively. The protein migrates as 23-25 kDa (C-terminus)  and 46-73 kDa (full length)  under reducing  (R)  condition  (SDS-PAGE)  due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT