Menin Antibody | R31676

Menin Antibody | R31676 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse

Application: WB

Buffer: N/A

Limitation: This Menin antibody is available for research use only.

Purity: Antigen affinity

Description: The MEN1 gene encodes Menin, a nuclear scaffold protein that regulates gene transcription by coordinating chromatin remodeling. It is mapped to 11q13.1. MEN1 is considered to act as a tumor suppressor gene. It has been found that that MEN1 inactivation by antisense RNA antagonizes transforming growth factor-beta-mediated cell growth inhibition. Overexpression in an inducible cell culture system downregulated the proximal promoter. In vitro studies have shown that the protein is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD. Additionally, MEN1 was essential to maintain MLL-associated myeloid transformation.

Immunogen: Human partial recombinant protein (AA 301-615) was used as the immunogen for this Menin antibody. Human MEN1 shares 93% and 94% amino acid sequence identity with mouse and rat, respectively.

Storage: After reconstitution, the Menin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.