MEG-1 (PTPN4), GST-tag | 30015

MEG-1 (PTPN4), GST-tag | 30015 | Gentaur US, UK & Europe Disrtribition

Category: Protein Phosphatase/Non-Receptor

Application: Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.

Background: PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP acts at junctions between the membrane and the cytoskeleton and has been shown to interact with glutamate receptor delta 2 and epsilon subunits. It also is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.

Description: MEG-1 protein tyrosine phosphatase (PTP-MEG-1), Genbank Accession No. NM_002830, a.a. 637-926 (catalytic domain) with N-terminal GST-tag, MW=60.3 kDa, expressed in an E. coli expression system.

Product Type: Protein

Shippement Condition: -80°C