MDM2 Polyclonal Antibody | E-AB-31995

MDM2 Polyclonal Antibody | E-AB-31995 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Mouse, Monkey

Host: Rabbit

Isotype: IgG

Application: WB, IHC-p, IF, ELISA

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Background: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Lead Time: 7~10 days

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthesized peptide derived from human MDM2 around the non-phosphorylation site of Ser166.

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000

Conjugation: Unconjugated

Calculated Molecular Weight: 55 kDa

Observed Molecular Weight: 90 kDa

Clonality: Polyclonal