Description
MDM2 Polyclonal Antibody | E-AB-31995 | Gentaur US, UK & Europe Disrtribition
Reactivity: Human, Mouse, Monkey
Host: Rabbit
Isotype: IgG
Application: WB, IHC-p, IF, ELISA
Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Background: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Lead Time: 7~10 days
Concentration: 1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Synthesized peptide derived from human MDM2 around the non-phosphorylation site of Ser166.
Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000
Conjugation: Unconjugated
Calculated Molecular Weight: 55 kDa
Observed Molecular Weight: 90 kDa
Clonality: Polyclonal
