Description
MDM2 Antibody | V7950-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: SMP14
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human, Mouse, Rat
Application: ELISA, WB, IHC-P
Buffer: N/A
Limitation: This MDM2 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: MDM2 is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53. It can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. Overexpression of MDM2 protein is detected in a variety of cancers.
Immunogen: Amino acids 154-167 were used as the immunogen for the MDM2 antibody.
Storage: Store the MDM2 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
