MDM2 Antibody | F42277-0.2ML

MDM2 Antibody | F42277-0.2ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse

Application: WB, IHC, ELISA

Buffer: N/A

Limitation: This anti-MDM2 antibody is available for research use only.

Purity: Purified

Description: MDM2 is a target of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle,apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5.

Immunogen: A portion of amino acids 393-424 from the human protein was used as the immunogen for this anti-MDM2 antibody.

Storage: Aliquot the anti-MDM2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.