MCC Antibody / Mutated in Colorectal Cancers | RQ6655

MCC Antibody / Mutated in Colorectal Cancers | RQ6655 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse, Rat

Application: WB, FACS, Direct ELISA

Buffer: Lyophilized from 1X PBS with 2% Trehalose

Limitation: This Mutated in Colorectal Cancers antibody is available for research use only.

Purity: Antigen affinity purified

Description: MUTATED IN COLORECTAL CANCERS (MCC) is a tumor suppressor gene. It is mapped to 5q22.2. This gene suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. MCC also Inhibits DNA binding of b-catenin/TCF/LEF transcription factors, and it is Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. What's more, MCC can interact with SCRIB (via phosphorylated PDZ-binding motif), EZR, SNX27, SLC9A3R1 and SLC9A3R2.

Immunogen: Recombinant human protein (amino acids M1-E234) was used as the immunogen for the Mutated in Colorectal Cancers antibody.

Storage: After reconstitution, the Mutated in Colorectal Cancers antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.