Mavs Antibody (Ips-1) | F47745-0.08ML

Mavs Antibody (Ips-1) | F47745-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Mouse

Application: WB, ELISA

Buffer: N/A

Limitation: This Ips-1 antibody is available for research use only.

Purity: Antigen affinity

Description: Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis (By similarity).

Immunogen: A portion of amino acids 1-30 from the mouse protein was used as the immunogen for this Ips-1 antibody.

Storage: Aliquot the Ips-1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.