Description
MARK1 Antibody | F40144-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS pH 7.4 with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse
Application: IHC, WB, ELISA
Buffer: N/A
Limitation: This MARK1 antibody is available for research use only.
Purity: Purified
Description: MARK is a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration. Expression of MARK causes the phosphorylation of MAPs at their KXGS motifs, thereby detaching MAPs from the microtubules and thus facilitating the transport of particles. This occurs without impairing the intrinsic activity of motors because the velocity during active movement remains unchanged. In primary retinal ganglion cells, transfection with tau leads to the inhibition of axonal transport of mitochondria, APP vesicles, and other cell components which leads to starvation of axons and vulnerability against stress. This transport inhibition can be rescued by phosphorylating tau with MARK
Immunogen: A portion of amino acids 6-40 from the human protein was used as the immunogen for this MARK1 antibody.
Storage: Aliquot the MARK1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
