Description
MAP3K14 Kinase Assay Kit | 78440 | Gentaur US, UK & Europe Disrtribition
Category: Kinase/Assay Kit
Application: Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.
Background: MAP3K14 (mitogen-activated protein kinase kinase kinase 14, also known as NF-kappa-beta-inducing kinase or NIK) is a Serine/Threonine Kinase of the MAPKK kinase family. This kinase is known for its non-canonical activation of transcription factor NFκB. Expressed in immune cells, it is activated by the interleukin-1 receptors and by receptors of the tumor-necrosis/nerve-growth factor (TNF/NGF) family and plays a role in the innate and adaptive immune response and regulates inflammation. Loss of MAP3K14 expression is associated with immune defects, whereas overexpression correlates with inflammation, metabolic diseases, or cancer.
Description: The MAP3K14 Kinase Assay Kit is designed to measure MAP3K14 kinase activity for screening and profiling applications using ADP-Glo® as a detection reagent.
Product Type: Assay Kit
Shippement Condition: -80°C
