Description
MAGE-1 Antibody | V3136-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Format: Purified
Clone: MA454
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human, Rat
Application: IHC-P
Buffer: N/A
Limitation: This MAGE-1 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: Recognizes a protein of 42-46kDa, identified as MAGE-1. This mAb does not cross-react with MAGE-2, -3, -4, -6 -9, -10, or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
Immunogen: Full length human protein was used as the immunogen for this MAGE-1 antibody.
Storage: Store the MAGE-1 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
