Macrophage / Histiocytoma Marker Antibody | V3092-100UG

Macrophage / Histiocytoma Marker Antibody | V3092-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Format: Purified

Clone: D11

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human, Rat

Application: IHC-P

Buffer: N/A

Limitation: This Macrophage / Histiocytoma Marker antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: In Western blotting, it detects an antigen of 125kDa in human liver and 135kDa in tumors of histiocytic origin. Comparative study of this mAb and a standard CD68 mAb showed that their antigens are different. Its antigen in all macrophage types studied is located on the plasma membrane and within cytoplasmic structures including lysosomes. This mAb shows a restricted reactivity to cells of the monocyte/macrophage system. It specifically reacts with blood monocytes and stains resident macrophages in a wide variety of human tissues. This mAb does not stain antigen-presenting cells, e.g., Langerhans cells. Reportedly, its reactivity is restricted to histiocytes and macrophages.

Immunogen: A membrane preparation from human hepatocytes was used as the immunogen for the Macrophage / Histiocytoma Marker antibody.

Storage: Store the Macrophage / Histiocytoma Marker antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).