Description
LYNB, GST-tag | 40472 | Gentaur US, UK & Europe Disrtribition
Category: Kinase/Cytoplasmic Tyrosine
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Background: LYN is a 56 kd tyrosine kinase that is similar to mouse T-lymphocyte-specific tyrosine kinase p56lck, v-yes, v-fgr and v-src and is expressed in a variety of tissues (1). LYN is expressed preferentially in B cells and can be coimmunoprecipitated with IgM suggesting that LYN is physically associated with membrane-bound IgM, and participates in antigen-mediated signal transduction (2). Crosslinking of membrane-bound IgM with antibody induces rapid increase in activities of LYN and LYN-associated phosphatidylinositol 3-kinase.
Description: Recombinant full-length human LYN B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST-tag. The gene accession number is BC059394.
Product Type: Protein
Shippement Condition: -80°C
