LXRB Antibody / NR1H2 | V8367-20UG

LXRB Antibody / NR1H2 | V8367-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: LXRB/2731

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: ELISA

Buffer: N/A

Limitation: This LXRB antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: The liver X receptors, LXRA (NR1H3) and LXRB (NR1H2) form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements. LXRB can inhibit proliferation and induce apoptosis of cancer cells.

Immunogen: Recombinant full-length human NR1H2/LXRB protein was used as the immunogen for the LXRB antibody.

Storage: Store the LXRB antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).