Description
LRP6 Antibody | F49462-0.4ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, IHC, ELISA
Buffer: N/A
Limitation: This LRP6 antibody is available for research use only.
Purity: Purified
Description: LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
Immunogen: A portion of amino acids 1531-1560 from the human protein was used as the immunogen for this LRP6 antibody.
Storage: Aliquot the LRP6 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
