LRP6 Antibody | F49462-0.08ML

LRP6 Antibody | F49462-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: WB, IHC, ELISA

Buffer: N/A

Limitation: This LRP6 antibody is available for research use only.

Purity: Purified

Description: LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.

Immunogen: A portion of amino acids 1531-1560 from the human protein was used as the immunogen for this LRP6 antibody.

Storage: Aliquot the LRP6 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.