Description
LKB1 Antibody (Liver Kinase B1) | F50223-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, FACS, IF, ELISA
Buffer: N/A
Limitation: This LKB1 antibody is available for research use only.
Purity: Purified
Description: LKB1 is a tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. [UniProt]
Immunogen: A portion of amino acids 19-48 from the human protein was used as the immunogen for this LKB1 antibody.
Storage: Aliquot the LKB1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
