Description
LILRB4 NFAT-Luciferase Reporter Jurkat Recombinant Cell Line | 79750 | Gentaur US, UK & Europe Disrtribition
Category: Immunotherapy/Cell Line
Application: • Screen for novel ligands of LILRB4
Background: Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4 (LILRB4) contains multiple Immunoreceptor Tyrosine-based Inhibitory Motifs (ITIMs). LILRB4 expression on Acute Myeloid Leukemia (AML) cells promotes tumor cell infiltration and suppresses T cell activity. Because LILRB4 is highly expressed on AML cells but not on normal hematopoietic stem cells, LILRB4 has been identified as a promising therapeutic target for CAR-T cells.
Description: Recombinant Jurkat cells constitutively expressing human LILRB4 (Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4, GenBank Accession #NM_001278426) and the firefly luciferase gene under the control of NFAT response elements.
Product Type: Cell Line
Shippement Condition: -80°C
