LIGHT: HVEM [Biotinylated] Inhibitor Screening ELISA Kit | EP-148-96tests

LIGHT: HVEM [Biotinylated] Inhibitor Screening ELISA Kit | EP-148| Gentaur Distribution US, UK & Europe

Tumor necrosis factor ligand superfamily member 14 (LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR) . LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.

Source: Tumor necrosis factor ligand superfamily member 14 (LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR) . LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.

Molecule: LIGHT.

Format: Solid.

Species: Human.

Application: This kit is developed for screening for inhibitors of human LIGHT binding to human HVEM.

Kit Component: This inhibitor screening ELISA kit is designed to facilitate the identification and characterization of new LIGHT pathway inhibitors. The assay takes advantage of our in house-developed binding of biotinylated human HVEM to immobilized human LIGHT in a functional ELISA assay, and employs a simple colorimetric ELISA platform. Briefly, we provide you with a human Biotinylated HVEM protein, a human LIGHT protein, an anti-LIGHT neutralizing antibody (as method verified Std.), and Streptavidin-HRP reagent.

Stability: The unopened kit is stable for 12 months from the date of manufacture if stored at 2°C to 8°C. The opened kit should be stored per components table. The shelf life is 30 days from the date of opening.

Storage Conditions: 2-8℃.

Shipping Conditions: RT