Description
LGR5 Antibody / GPR49 | RQ4782 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: Antibody in PBS with 0.02% sodium azide and 50% glycerol
Format: Purified
Clone: CHF-12
Host Animal: Rabbit
Clonality: Rabbit Monoclonal
Species Reactivity: Human
Application: WB
Buffer: N/A
Limitation: This GPR49 antibody is available for research use only.
Purity: Affinity purified
Description: 'G-protein coupled receptor 49,' or 'Leucine-rich repeat-containing G-protein coupled receptor 5' is a receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. [UniProt]
Immunogen: A synthetic peptide specific to human GPR49 / LGR5 was used as the immunogen for the GPR49 antibody.
Storage: Store the GPR49 antibody at -20 °C.
