LGR5 Antibody / GPR49 | RQ4782

LGR5 Antibody / GPR49 | RQ4782 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: Antibody in PBS with 0.02% sodium azide and 50% glycerol

Format: Purified

Clone: CHF-12

Host Animal: Rabbit

Clonality: Rabbit Monoclonal

Species Reactivity: Human

Application: WB

Buffer: N/A

Limitation: This GPR49 antibody is available for research use only.

Purity: Affinity purified

Description: 'G-protein coupled receptor 49,' or 'Leucine-rich repeat-containing G-protein coupled receptor 5' is a receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. [UniProt]

Immunogen: A synthetic peptide specific to human GPR49 / LGR5 was used as the immunogen for the GPR49 antibody.

Storage: Store the GPR49 antibody at -20 °C.