LGR5 Antibody | F48167-0.4ML

LGR5 Antibody | F48167-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: IHC, WB, ELISA

Buffer: N/A

Limitation: This anti-LGR5 antibody is available for research use only.

Purity: Purified

Description: LGR5/GPR49 is a receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. [UniProt]

Immunogen: A portion of amino acids 605-638 from the human protein was used as the immunogen for this anti-LGR5 antibody.

Storage: Aliquot the anti-LGR5 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.