LDN-57444 | 27706-1

LDN-57444 | 27706-1 | Gentaur US, UK & Europe Disrtribition

Category: Ubiquitination/Inhibitors / Activators

Application: Useful for the inhibition of Ubiquitin C-terminal Hydrolase (UCH-L1) in drug discovery studies.

Background: N/A

Description: LDN-57444 is a cell permeable ubiquitin C-terminal hydrolase (UCH-L1) inhibitor (Ki=0.4 µM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis and causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. LDN-57444 is a useful tool to study UCH-L1 in different pathological conditions such as cancer and neurodegeneration.

Product Type: Inhibitors/Activators

Shippement Condition: gel packs