Description
LCMV Glycoprotein C (R262A) Protein, His Tag | CLN-L52H2-100ug| Gentaur Distribution US, UK & Europe
Lymphocytic choriomeningitis virus (LCMV) is a spherical enveloped virus with an RNA genome consisting of two negative single-stranded RNA segments, the large (L) strand and the small (S) strand. The L strand encodes the virus polymerase (L) and a small zinc finger motif protein (Z) ; the smaller (S) segment encodes the two main structural proteins: virus nucleoprotein (NP) and glycoprotein (GP) precursor (GPC). The GP of LCMV serves as virus attachment protein to its receptor on host cells and is a key determinant for cell tropism, pathogenesis, and epidemiology of the virus. The GP undergoes post-translational cleavage and results in the synthesis of two mature virion glycoproteins, GP-1 (40 to 46 kDa) and GP-2 (35 kDa). The spikes present on the virion envelope are dictated by tetramer formation of GP-1 and GP-2. The peripheral GP-1 is implicated in receptor binding, and the transmembrane GP-2 is structurally similar to the fusion active membrane proximal portions of the glycoproteins of other enveloped viruses.
Source: LCMV Glycoprotein C (R262A) Protein, His Tag (CLN-L52H2) is expressed from human 293 cells (HEK293). It contains AA Met 59 - Asp 438 (Accession # AJ297484.1 (R262A) ).
Format: Powder.
Tag: C-10×His.
Expression System: HEK293.
Expression Region: Met 59 - Asp 438.
Conjugate: Unconjugated.
Molecular Weight: 48.6 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 48.6 kDa. The protein migrates as 66-70 kDa and 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
