Description
LC3A/B Antibody | F54060-0.1ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Format: Purified
Clone: 3E9-E5-C9
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human, Rat
Application: WB
Buffer: N/A
Limitation: This LC3A/B antibody is available for research use only.
Purity: Protein G affinity
Description: LC3A:Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. [UniProt]
LC3B:Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. [UniProt]
Immunogen: A synthetic LC3B peptide was used as the immunogen for this LC3A/B antibody.
Storage: Store the LC3A/B antibody at -20 °C.
