Langerin Antibody / CD207 | V8856-100UG

Langerin Antibody / CD207 | V8856-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: rLGRN/1821

Host: Mouse

Clonality: Recombinant Mouse Monoclonal

Isotype: Mouse IgG1, kappa

Species Reactivity: Human

Application: ELISA

Application Details: ELISA: 2-4ug/ml (order BSA-free format for coating)

Application Note: Optimal dilution of the recombinant Langerin antibody should be determined by the researcher.

Purity: Protein A/G affinity

Description: Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.

Immunogen: A portion of amino acids 74-213 was used as the immunogen for the recombinant Langerin antibody.

Storage: Aliquot the recombinant Langerin antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.

Localization: Cell surface and cytoplasmic