Langerin Antibody / CD207 | V7993-20UG

Langerin Antibody / CD207 | V7993-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: LGRN/1821

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: ELISA, WB

Buffer: N/A

Limitation: This Langerin antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.

Immunogen: A recombinant human partial protein (amino acids 74-213) was used as the immunogen for the Langerin antibody.

Storage: Store the Langerin antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).