Description
Langerin Antibody / CD207 | V7993-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: LGRN/1821
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: ELISA, WB
Buffer: N/A
Limitation: This Langerin antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.
Immunogen: A recombinant human partial protein (amino acids 74-213) was used as the immunogen for the Langerin antibody.
Storage: Store the Langerin antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
