L3MBTL1, GST-tag | 55000

L3MBTL1, GST-tag | 55000 | Gentaur US, UK & Europe Disrtribition

Category: Methyl-lysine Reader/Protein

Application: Useful for the study of Polycomb group (PcG) proteins, protein binding assays, screening inhibitors, and selectivity profiling.

Background: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyl-lysine residues on target proteins, therey acting as a reader of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E atLys26 (H1bK26me1 and H1bK26me2) and histone H4 at Lys-20 (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at Lys-382, leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at Lys-860. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.

Description: Human lethal(3)malignant brain tumor-like protein 1 (L3MBTL1), GenBank Accession No. NM_015478, a.a. 191-530 with N-terminal GST-tag, MW = 65.5 kDa, expressed in an E. coli cell expression system.

Product Type: Protein

Shippement Condition: -80°C