Ku80 Antibody / XRCC5 | V8929-100UG

Ku80 Antibody / XRCC5 | V8929-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: XRCC5/7315

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: WB, IHC-P

Buffer: N/A

Limitation: This XRCC5/Ku80 antibody is available for research use only.

Purity: Protein A/G affinity

Description: The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (or p70) and Ku-86 or (p86) which is also known by the synonym Ku-80 or (p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma-polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Ku has several functions, including cell signaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription by virtue of its DNA binding activity; serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters.

Immunogen: A portion of amino acids 300-500 was used as the immunogen for the XRCC5/Ku80 antibody.

Storage: Aliquot the XRCC5/Ku80 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.