Description
Ku80 Antibody | R30724 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, IHC-P, ICC, IF, FACS
Buffer: N/A
Limitation: This Ku80 antibody is available for research use only.
Purity: Antigen affinity
Description: XRCC5 (X-ray Repair, Complementing Defective, In Chinese Hamster, 5), also known as Ku80 or Ku86, is a protein that in humans, is encoded by the XRCC5 gene. The XRCC5 gene encodes the 80-kD subunit of the Ku autoantigen, a heterodimer which contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the nonhomologous end joining(NHEJ) pathway. Human colon cancer cells heterozygous for Ku80 are haploinsufficient with an increase in polyploid cells, a reduction in cell proliferation, elevated p53 levels, and a slight hypersensitivity to ionizing radiation. Functional inactivation of the second Ku80 allele results in cells with a drastically reduced doubling time. The locus is essential in human somatic tissue culture cells by experiments demonstration. A rare microsatellite polymorphism in the protein is associated with cancer in patients of varying radiosensitivity.
Immunogen: An amino acid sequence from the C-terminus of human Ku80 (KFSEEQRFNNFLKAL) was used as the immunogen for this Ku80 antibody.
Storage: After reconstitution, the Ku80 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
